making crack with levamisole hydrochloride

Pope, Jeffrey D Drummer, Olaf H Schneider, Hans GĬocaine use in Australia is increasing, with approximately 2.5% of the surveyed population having used cocaine. The cocaine cutting agent levamisole is frequently detected in cocaine users. Most important is the identification of synergism for the levamisole/cocaine interaction, which now requires further study in mammals. The present results provide the first experimental evidence that levamisole enhances cocaine's action inÂ vivo. For combination experiments, a submaximal concentration of cocaine produced CPP that was enhanced by inactive concentrations of levamisole, indicating synergism. In conditioned place preference (CPP) experiments, cocaine produced a significant preference shift in contrast, levamisole was ineffective at all concentrations tested. For combined administration of the two agents, isobolographic analysis revealed that the observed stereotypical response was enhanced relative to the predicted effect, indicating synergism for the interaction. Acute exposure to levamisole or cocaine produced concentration-dependent increases in stereotyped movements. We specifically investigated effects of levamisole on cocaine's stereotypical and place-conditioning effects in an established invertebrate (planarian) assay. An alternative possibility, and one investigated here, is that levamisole alters cocaine's action inÂ vivo. One explanation for the addition of levamisole to cocaine is that it increases the amount of product and enhances profits. Levamisole is estimated by the Drug Enforcement Agency (DEA) to be present in about 80% of cocaine seized in the United States and linked to debilitating, and sometimes fatal, immunologic effects in cocaine abusers. Tallarida, Christopher S Egan, Erin Alejo, Gissel D Raffa, Robert Tallarida, Ronald J Rawls, Scott M Levamisole and cocaine synergism: a prevalent adulterant enhances cocaine's action in vivo.

Making crack with levamisole hydrochloride